Advancing non-clinical immunogenicity testing with ex vivo human skin models
Poster – SOT 2025
Thank you for your interest in our research on non-clinical immunogenicity testing.
Understanding immune responses—whether intended or off-target—is critical for developing safe and effective therapeutics. Our latest research highlights the power of ex vivo human skin models in providing clinically relevant, non-animal testing solutions.
Explore the findings below:
What’s Inside:
• White paper: A summary of the data showcased in our conference poster, presented at the FDA-CRCG meeting in October 2024.
• Publication: The full peer-reviewed study behind the poster.
• E-poster presentation: A quick visual overview of key findings.
Access the research
White paper
A new in vitro framework for assessing immunogenicity using comprehensive profiling of injectable human skin modules
Peer-Reviewed Publication
Scholaert M, Peries M, Braun E, et al. Multimodal profiling of biostabilized human skin modules reveals a coordinated ecosystem response to injected mRNA-1273 COVID-19 vaccine. Allergy. 2024; 79: 3341-3359.
E-poster
Longitudinal maintenance of human skin viability in HypoSkin®: a drug development platform for immunogenicity and toxicity assessment using advanced multi-omics profiling (3677/A137)
