Cosmetic claim substantiation
Innovative cosmetic efficacy studies
A new approach to cosmetic claim substantiation
Without harming humans or animals
Genoskin uses an innovative approach to help the cosmetic and aesthetic industry substantiate their claims and assess the efficacy and safety of cosmetic ingredients and injectables without harming either humans or animals. We combine live human skin platforms and expert tools to deliver cosmetic and aesthetic efficacy studies with high-quality results in order to substantiate your claims.
Animal-free
Our unique human data generation platforms provide a reliable alternative to animal testing, using real, live human skin.
Cosmetic Claim
Our skin platforms are suitable for a wide range of compounds requiring topical, systemic or intradermal administration, e.g. fillers.
Testing
Our platforms allow to study your compound on different donors to reflect the diversity of your target group and the human population.
Platform
We provide a unique view into efficacy, cellular regeneration, longevity,… thanks to our dedicated Mantis® spatial biology platform.
Efficacy studies for cosmetic ingredients
Test your compounds on live human skin
When it comes to cosmetic claim substantiation, NativeSkin® is our most popular data generation platform. NativeSkin® is real, donated human skin that is kept alive for 7 days thanks to our unique technology. This approach allows you to test your compounds on real human skin while observing live human skin response for an entire week. And all of this, without harming either humans or animals. Our NativeSkin access® skin models are available for shipment worldwide.
Innovative solutions for innovative cosmetics
Reliable data for all types of cosmetic ingredients & compounds
Constant adaptation and innovation are key to the cosmetic industry in order to meet market and customer expectations. To cater to the needs of all cosmetic companies, Genoskin not only offers skin models for compounds and ingredients that require topical or systemic application, we’re the only company in the world that provides live human skin platforms to test response to subcutaneous injection. To this effect, we use our Hyposkin® model, which, in addition to the live human dermis and epidermis contained in NativeSkin®, also includes human adipose tissue to make it suitable for subcutaneous and intradermal testing. However, our model for subcutaneous injection is only available as an in-house service for custom studies.
Topical application
Subcutaneous injection
Systemic administration
Study efficacy for multiple donors
Include donor diversity to increase data relevance
Since our human data generation platforms only contain donated skin, it is possible to conduct studies on multiple donors to represent the diversity of the human population or of your target audience. The characteristics of our skin models are donor-dependent and are one of the great strengths of our approach. They reflect natural biological diversity in the general population, allowing for more accurate and relevant study results.
Substantiate all your cosmetic claims
A quick overview of the studies we can conduct for you
Over the years, Genoskin has acquired unique expertise in skin biology and immunology and helped numerous customers obtain the results they need. Below you’ll find a quick overview of the studies we conduct routinely in our lab. Should you be looking for something that is not listed, don’t hesitate to get in touch so we can help you design the perfect study to substantiate your claim.
Protection against UV-exposure
Examples of scientific publications
- A human skin model to evaluate the protective effect of compounds against UVA damage
- Melatonin, bakuchiol and ascorbyl tetraisopalmitate synergize to modulate gene expression and restore Hypoxia-Inducible Factor 1 signaling in UV-exposed skin
- Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation
- SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
- Integrating targeted gene expression and a skin model system to identify functional inhibitors of the UV activated p38 MAP kinase
- Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo
Protection from pollution
Examples of scientific publications
Topical absorption & hydration
Examples of scientific publications
- Mapping 2D- and 3D-distributions of metal/metal oxide nanoparticles within cleared human ex vivo skin tissues
- Ex vivo visualization and extended release from a dissolvable microarray
- In vitro Dermal Absorption of Hydroquinone: Protocol Validation and Applicability on Illegal Skin-Whitening Cosmetics
- A Novel Explant Model for Skin Delivery Assessment
Effects on skin metabolism
Examples of scientific publications
Anti-aging & anti-wrinkle properties
Examples of scientific publications
- Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
- Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
- The anti-wrinkles properties of sodium acetylated hyaluronate
- Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
- Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
- Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects
- Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
- An Efficient Means to Mitigate Skin Inflammaging by Inhibition of the NLRP3 Inflammasome and Nfkb Pathways: A Novel Epigenetic Mechanism
Effects on skin barrier function
Examples of scientific publications
- The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity
- A proof-of-concept study utilising 2D NMR spectrometry for in situ characterisation and quantitation of key biomarkers and actives in tape stripped ex vivo human skin
- Barrier disruption, dehydration and inflammation: Investigation of the vicious circle underlying dry skin