NativeSkin^® & UV Testing

Traditional UV testing often struggles to capture the complexity of real human skin. Architecture, pigmentation, barrier function, immune responses, and repair mechanisms all shape how skin truly reacts to UV exposure, and oversimplified models can miss critical biology.

In this application note, we explore how NativeSkin^®, an ex vivo human skin model, enables a more physiologically relevant approach to UV research. By preserving intact human skin with functional immune and metabolic activity, NativeSkin^® supports non-clinical evaluation of UV-induced damage, photoprotection, and repair pathways—without animal testing.

Through selected case studies and experimental insights, the app note illustrates how NativeSkin^® can be applied to:

• Investigate UVB- and UVA-induced DNA damage and apoptosis
• Assess sunscreen and active ingredient efficacy beyond sunburn endpoints
• Study immune modulation, inflammation, and donor-specific responses
• Model complex, real-life exposure scenarios, including combined environmental stressors

Download the application note to explore how NativeSkin^® supports ethical, human-relevant, and translational research in UV testing, phototoxicity assessment, and photobiology.