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Preclinical evaluation of an energy-driven device for localized skin delivery of nucleic acids
Did you miss the live session? The full webinar recording is now available to watch on demand. Explore preclinical insights into an energy-driven, microneedle-based device enabling localized, non-viral delivery of naked nucleic acids to skin, highlighting transgene expression, immune activation, and the current opportunities and limitations of mechanically driven delivery approaches.
Energy-Based Device for Nucleic Acid Delivery to Skin
Efficiently delivering nucleic acids to skin remains one of the key challenges in developing non-viral technologies. Overcoming this barrier is essential for advancing next-generation vaccines, immunotherapies, and gene-based dermatological treatments. This webinar examines how energy-assisted mechanical delivery may provide a promising approach to address this challenge.
In this session from Genoskin’s webinar series, we explore a novel energy-driven, microneedle-based device designed to enable localized, non-viral delivery of naked nucleic acids to skin. The presentation highlights preclinical data demonstrating transgene expression and immune activation following delivery, while also discussing the current opportunities and limitations of mechanically driven nucleic acid delivery strategies.
Who Should Watch
This webinar is particularly relevant for researchers and developers working in:
- Drug delivery technologies
- Drug delivery devices
- Gene therapy
- Vaccine development
- Immunology
Watch the Replay
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About the speaker:
Dr. Ria Michalaki
Vice President of R&D at Piezo TherapeuticsDr. Ria Michalaki, PhD, is Vice President of Research and Development at Piezo Therapeutics, where she leads translational research efforts focused on non-viral nucleic acid delivery and device-enabled gene delivery technologies. Her work spans preclinical model development, skin biology, and energy-based delivery platforms. She received her PhD in Chemical Engineering from Stanford University and completed postdoctoral training at the Georgia Institute of Technology.
Additional resources on Dr. Michalaki’s research:
Michalaki, E., Van Zanten, A., Najjar, J., & Byagathvalli, G. A piezoelectric electroporator (Piezopen) for enhanced “naked” RNA vaccine delivery. bioRxiv, 2025. (preprint) doi: https://doi.org/10.1101/2025.02.07.637103
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