Top-level science through the eyes of an expert.

The next episode of the Genoskin Webinar series is now scheduled on October 17, 2024 at 8 a.m. (PST), 11 a.m. (EST), 5 p.m. (CET). The webinar is open to English-speaking participants with a solid scientific background. Featured speaker is Dr. Manon Scholaert, Scientist at Genoskin.

The field of drug development is witnessing a remarkable surge in the development of innovative strategies. There is a need to develop technological platforms capable of generating human data prior to progressing to clinical trials.

In this webinar, we introduce a new, flexible solution designed for the comprehensive monitoring of the human skin ecosystem’s response to immunogenic drugs over time. This solution, based on unique bioengineering techniques that preserve surgical resections in a long survival state, allows for the first time a comprehensive analysis of resident immune cells response at both organ and single-cell levels. Using the mRNA-1273 COVID-19 vaccine as a case study, we will demonstrate how our platform characterizes the sequential molecular events triggered upon detection of the exogenous substance.

Our findings highlight that the vaccine consistently targets DC/macrophages and mast cells, regardless of the administration route, while promoting specific cell–cell communications in surrounding immune cell subsets. Given its direct translational relevance, this approach provides a multiscale vision of genuine human tissue immunity that could pave the way toward the development of new vaccination and drug development strategies.