Human-based technology
for reliable results
Human-based technology
for reliable results
Human data generation technologies to drive your research forward
Genoskin provides advanced human-based models designed to serve as ethical and scientifically robust alternatives to animal testing. These models offer more predictive and translatable solutions, enabling faster research progress and reducing the risks of failure, effectively bridging the gap between non-clinical and clinical stages.
By utilizing donated, ethically sourced real human skin tissue, Genoskin develops innovative and reliable skin models. In addition to these advanced models, Genoskin supplies human primary mast cells for complementary in vitro testing. These solutions enable the efficient and reliable testing of chemical compounds, pharmaceuticals, cosmetic products, and medical devices without the need for animal testing.
Real human skin models
Preserving human skin viability is a key challenge in developing ex vivo models. Genoskin addresses this with standardized steps to rapidly biostabilize skin biopsies, maintaining an air-liquid interface and natural biomechanical properties. This process produces living, immunocompetent models that accelerate candidate selection in research.
Ethically sourced skin resections, primarily from abdominoplasties, are embedded in a solid gel-like matrix with a silicone ring to emulate natural tension. Cultured in a chemically defined, animal-free medium, these models remain viable for up to seven days, providing accurate human data for research and development.
HypoSkin®:
Advancing subcutaneous injection research
HypoSkin® is a live ex vivo human skin model that includes the epidermis, dermis, and hypodermis layers, making it the first model on the market specifically designed for research on subcutaneous injection in human skin. Its versatility extends to studies involving other administration routes, such as transdermal application, intradermal injection, device insertion, and infusion, enabling broad research applications.
This model is ideal for efficacy and toxicity studies, providing key insights into immune responses and supporting therapeutic and vaccine development. HypoSkin® replicates human skin’s complexity, making it a valuable tool for non-clinical evaluations.
NativeSkin®:
Versatile models for diverse skin research applications
The NativeSkin® model supports topical and systemic studies, utilizing human epidermis and dermis for accurate applications. The NativeSkin® platform proposes a range of specialized models for diverse research needs:
- Tape Stripped NativeSkin®: Ideal for studying skin barrier function, reconstruction, and epidermal delivery.
- WoundSkin®: Features a 2 mm skin defect for wound healing, infection, and bacterial colonization research.
- HairSkin®: Derived from facial lift samples with high follicle density for skincare and haircare studies.
These models provide targeted solutions for advancing dermatological and pharmaceutical research.
NativeSkin®:
Versatile models for diverse skin research applications
The NativeSkin® model supports topical and systemic studies, utilizing human epidermis and dermis for accurate applications. The NativeSkin® platform proposes a range of specialized models for diverse research needs:
- Tape Stripped NativeSkin®: Ideal for studying skin barrier function, reconstruction, and epidermal delivery.
- WoundSkin®: Features a 2 mm skin defect for wound healing, infection, and bacterial colonization research.
- HairSkin®: Derived from facial lift samples with high follicle density for skincare and haircare studies.
These models provide targeted solutions for advancing dermatological and pharmaceutical research.
InflammaSkin®:
A T-cell-driven psoriasis model for advanced inflammation research
InflammaSkin® is a unique ex vivo psoriasis-like model for studying human skin responses to anti-psoriasis drugs administered topically or subcutaneously. Resident T cells are activated using a proprietary cocktail and cultured for up to seven days in a cytokine-supplemented medium, inducing Th17/Th1 polarization. It is the only ex vivo model with T cell-driven inflammation of this phenotype, suitable for testing prophylactic and therapeutic biologics or small molecule drugs.
Human Mast Cells
Genoskin provides human primary mast cells for drug efficacy and toxicity testing, offering critical insights into immune responses and drug mechanisms. Using a proprietary process, mature mast cells are generated from healthy adult donors’ blood in one month, replicating the phenotype of connective tissue-type mast cells. These cells offer a reliable platform for studying immune mechanisms and testing therapeutic compounds in human-focused research.
Human Mast Cells
Genoskin provides human primary mast cells for drug efficacy and toxicity testing, offering critical insights into immune responses and drug mechanisms. Using a proprietary process, mature mast cells are generated from healthy adult donors’ blood in one month, replicating the phenotype of connective tissue-type mast cells. These cells offer a reliable platform for studying immune mechanisms and testing therapeutic compounds in human-focused research.
