Top-level science through the eyes of an expert.
Join us for the next session in Genoskin’s webinar series, where we explore cutting-edge advancements in drug delivery and therapeutic innovation. This session will feature an in-depth presentation on polymer prodrug nanocarriers, showcasing a novel approach to controlled and efficient drug release.
This episode of Genoskin’s webinar series is scheduled on March 24th, 2025 at 8 a.m. (PST), 11 a.m. (EST), 5 p.m. (CET).
This webinar explores new research on polymer-drug conjugates in cancer therapy. Dr. Julien Nicolas, Researcher Director at Institut Galien Paris-Saclay and CNRS, will present findings on innovative polymer prodrug nanocarriers created using the “drug-initiated” method.
Subcutaneous administration of vesicant/irritant anticancer drugs from water-soluble polymer prodrugs
Polymer-drug conjugates offer distinct advantages over traditional nanocarriers, such as eliminating burst release, enabling high drug loading, and providing spatio-temporal control over drug release. In this webinar, we will explore a breakthrough approach: the “drug-initiated” method, which enables the controlled polymerization of vinyl polymers from anticancer drug-bearing initiators. This unique technique developed by Dr. Julien Nicolas and his team has led to the development of well-defined, high-drug-content polymer prodrugs with demonstrated in vitro and in vivo anticancer activity.
This session is a must-attend for scientists, researchers, and professionals in drug delivery and oncology who are interested in the next-generation polymer-based therapeutics.
Register now to stay at the forefront of drug delivery innovation!
About the speaker:
Dr. Julien Nicolas
CNRS Director of Research, Institut Galien Paris-Saclay, head of the group Nanomedicines for the treatment of severe diseasesJulien Nicolas earned his PhD in 2005 from University Pierre and Marie Curie (Paris, France), specializing in nitroxide-mediated and emulsion polymerization. After a postdoc at University of Warwick (UK) on polymer-protein bioconjugates, he joined CNRS in 2007 as a researcher at Institut Galien Paris-Saclay, later becoming Director of Research (2016) and Group Leader (2019).
His work focuses on advanced macromolecular synthesis and polymer-based nanomedicines, particularly polymer nanoparticles and prodrug nanocarriers for cancer therapy. He has authored 130+ peer-reviewed articles, 7 patents, and 13 book chapters, and co-founded Imescia, a startup developing hydrophilic polymer prodrugs for anticancer treatments.
Dr. Nicolas serves as Associate Editor for Chemistry of Materials (ACS) and sits on the editorial boards of ACS Macro Letters, Macromolecules, and Polymer Chemistry. His awards include the 2016 SCF/GFP Award, 2017 Polymer Chemistry Lectureship, 2017 Novacap Prize, 2018 Biomacromolecules/Macromolecules Young Investigator Award, the 2023 Prix des Innovateurs de la Région Île-de-France, and the 2024 Jean-Pierre Pascault Award (GFP).
Additional resources on Dr. Nicolas’ work
• Subcutaneous Drug Delivery from Nanoscale Systems. Tomasini, L.; Ferrere, M.; Nicolas, J. Nature Rev. Bioeng. 2024. DOI: 110.1038/s44222-024-00161-w
• Coarse-Grained Model-Assisted Design of Polymer Prodrug Nanoparticles with Enhanced Cytotoxicity: A Combined Theoretical and Experimental Study. Gao, P.; Ha-Duong, T.; Nicolas, J. Angew. Chem.; Int. Ed. 2024. DOI: 10.1002/anie.20231605
• Degradable Polyisoprene by Radical Ring-Opening Polymerization and Application to Polymer Prodrug Nanoparticles. Lages, M.; Pesenti, T.; Zhu, C.; Le, D.; Mougin, J.; Guillaneuf, Y.; Nicolas, J. Chem. Sci. 2023, 14, 3311
• A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs. Bordat, A.; Boissenot, T.; Ibrahim, N.; Ferrere, M.; Levêque, M.; Potiron, L.; Denis, S.; Garcia-Argote, S.; Carvalho, O.; Abadie, J.; Cailleau, C.; Pieters, G.; Tsapis, N.; Nicolas, J. J. Am. Chem. Soc. 2022, 144, 18844
• Vinyl Copolymers with Faster Hydrolytic Degradation than Aliphatic Polyesters and Tunable Upper Critical Solution Temperatures. Bossion, A.; Zhu, C.; Guerassimoff, L.; Mougin, J.; Nicolas, J. Nature Commun. 2022, 13, 2873
• Supramolecular Organization of Polymer Prodrug Nanoparticles Revealed by Coarse-Grained Simulations. Gao, P.; Nicolas, J.; Ha-Duong, T. J. Am. Chem. Soc. 2021, 143, 42
• A Facile Route to Heterotelechelic Polymer Prodrug Nanoparticles for Imaging, Drug Delivery and Combination Therapy. Vinciguerra, D.; Denis, S.; Mougin, J.; Jacobs, M.; Guillaneuf, Y.; Mura, S.; Couvreur, P.; Nicolas, J. J. Control. Release 2018, 286, 485
• Degradable Polymer Prodrugs with Adjustable Activity from Drug-Initiated Radical Ring-Opening Copolymerization. Guégain, E.; Tran, J.; Deguettes, Q.; Nicolas, J. Chem. Sci. 2018, 9, 8291
• Degradable Vinyl Polymers for Biomedical Applications. Delplace, V.; Nicolas, J. Nature Chem. 2015, 7, 771
• Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Harrisson, S.; Nicolas, J.; Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Angew. Chem., Int. Ed. 2013, 52, 1678
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