Skin Models

CBD has been hailed as the hottest new ingredient in skin care, with CBD-containing products appearing on the market at a record pace over the past 2 years. CBD products span all areas of the personal care industry, from skincare to hair care to active cosmetics. Claims are diverse and include anti-inflammatory, anti-itch, anti-acne, and anti-aging. Despite the widespread use of CBD in topical cosmetic products, there is limited data regarding the effects of cannabinoids on the skin. Most studies have either been carried out using monolayer cell cultures with a single cell type or consumer-based surveys. Studies with 2D cells have shown changes in biological mechanisms that range from regulation of inflammation via NRF2, NFKB, and inflammasome pathways, to melanogenesis, cell proliferation and apoptosis, and keratinocyte differentiation.

In order to establish a testing method for evaluating CBD and CBD-like compounds and formulations, a series of studies were performed to characterize the gene expression response to CBD in the skin. Studies were performed to correlate gene expression changes in an in vitro skin model containing keratinocytes and fibroblasts and with an ex vivo skin tissue system (NativeSkin^®).

After submitting this form, you will receive an email with the link to access our poster.