Toxicity studies

Dive into injection site reaction research

Reactogenicity assessment & biological pathways analysis

Poster #1 – Automated prediction of drug reactogenicity at the site of injection, by combining natural human skin & computational inference of biological pathways.

Emeline Pagès1, Mathias Peries1, Emilie Braun1, Manon Scholaert1,2, Katarzyna Polak1, Nicolas Gaudenzio1,21Genoskin SAS, Toulouse, France – 2Toulouse Institute for Infectious and Inflammatory Diseases (Infinity) INSERM UMR1291 – CNRS UMR5051 – University Toulouse III, France – 3Genoskin Inc, Salem MA, USA


Injection site reaction mitigation (customer poster)

Poster #2 – Mitigation of Injection site reactions after subcutaneous administration of Dalcinonacog Alfa (DalcA) in Hemophilia B using preclinical models.

Natacha Le Moan1, Lauren Kelly1, Eric Merle2, Pascal Descargues2, Nicolas Gaudenzio2, Hugo Gagnon3, Anju Chatterji1, Grant E. Blouze11Catalyst Biosciences, South San Francisco, CA, USA – 2Genoskin, Inc., 4 Technology Way, Salem, MA, 01970, USA – 3Phenoswitch Biosciences, 975 Rue Léon-Trépanier, Sherbrooke, QC J1G 5J6, Canada.


Local tolerance upon subcutaneous injection

Poster #3 – Evaluation of local inflammatory reactions following subcutaneous injection of a pro-inflammatory cocktail in a fully human ex vivo skin model.

C. Jardet (Genoskin), E. Pagès (Genoskin), E. Raude (Genoskin), F. Seeliger (AstraZeneca), L. Brandén (AstraZeneca), E. Braun (Genoskin), M. Ingelsten (LAAS-CNRS), P. Descargues (Genoskin)


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