Skin Models

Advancing medical device development with ex vivo human skinMedical devices are evolving rapidly, becoming more sophisticated and diverse in their applications. From injectable drug delivery systems to wound dressings, wearable sensors, and microneedles, these innovations must undergo rigorous testing to ensure safety, functionality, and biocompatibility. However, as medical devices become more complex, so do the challenges associated with their preclinicalRead more

NativeSkin® & CosmeticsApplication NoteNativeSkin®: A Human Skin Model for Cosmetic Testing Discover NativeSkin®, an advanced ex vivo human skin model designed to provide a physiologically relevant and cruelty-free platform for cosmetic testing. This patented model preserves the structure, cellular complexity, and barrier function of real human skin, ensuring reliable assessments of efficacy (e.g., hydration, anti-aging, barrier repair) and safety (e.g.,Read more

Beyond animal models: The role of human skin in ADME testingADME (Absorption, Distribution, Metabolism, and Excretion) testing plays a vital role in modern drug development by improving candidate selection, reducing failures, enhancing safety assessments, ensuring regulatory compliance, and ultimately saving time and resources in bringing new drugs to market. Traditionally, ADME testing has relied on animal models and in vitroRead more

HairSkin®Human skin model with hair folliclesHairSkin®: the first ex vivo human skin model with mature pilosebaceous units HairSkin® is a cutting-edge ex vivo human skin model, developed with tissue containing fully mature pilosebaceous units. HairSkin® is designed to meet the requirements of both pharmaceutical and cosmetic industries and to empower innovation in dermatology, cosmetics, and personal care. Thanks to aRead more

From human skin to human data: Advancing immunogenicity testing with human modelsIn a public workshop organized by the FDA-CRCG group, Dr. Nicolas Gaudenzio, CSO of Genoskin, introduced an innovative platform for assessing immune reactions in response to injected substances using human skin explants. His talk, titled "A new in vitro framework for assessing immunogenicity using comprehensive profiling of injectable humanRead more

This application note highlights new comparative data on T cell dynamics in HypoSkin^® and InflammaSkin^®, generated using flow cytometric analysis.