Cosmetics & Personal Care

Human ex vivo NAMs for cosmetic innovation
and claim-support studies

Find the right starting point for cosmetic research program

Cosmetic innovation requires more than simple viability or irritation data. Cosmetic and personal care companies need human-relevant evidence to understand how active ingredients, formulations, and finished products interact with living skin before moving into clinical or consumer studies.

Genoskin’s ex vivo human skin models preserve natural skin architecture, donor variability, resident immune cells, and biologically relevant tissue responses. From barrier function and hydration to inflammation, aging, photodamage, scalp biology, and advanced molecular profiling, Genoskin helps cosmetic teams generate deeper insight into product performance and mechanism of action.

Use our ready-to-use models for in-house studies, or work with our CRO team to design customized studies that support cosmetic R&D, formulation optimization, and claim-support strategies.

Safety, Tolerance & Immune Response

Evaluate early safety signals, irritation-related markers, tissue viability, skin barrier integrity, inflammatory pathways, cytokine release, and donor-dependent sensitivity responses to cosmetic ingredients, formulations, and finished products.

EXPLORE →

Delivery

Assess skin penetration, formulation performance, and ingredient bioavailability in ex vivo human skin to support delivery strategy and product optimization.

EXPLORE →

Skin Biology, Efficacy Claims & Advanced Analytics

Investigate the biological effects of cosmetic ingredients and formulations on skin hydration, aging, UV-induced damage, oxidative stress, tissue repair, dermal remodeling, scalp and hair follicle biology, and sebaceous gland activity. Generate robust claim-support data through histology, cytokine profiling, gene expression, spatial biology, image analysis, and bioinformatics.

EXPLORE →

Human skin models for cosmetic R&D

Order ready-to-use models for in-house studies, or work with our CRO team for custom cosmetic study designs.

NativeSkin®

A live ex vivo human skin model preserving epidermis, dermis, immune cells, skin appendages, and donor-specific responses. Suitable for:

  • Topical cosmetic testing
  • Barrier and hydration studies
  • Irritation and tolerance screening
  • Anti-pollution, photodamage, and skin repair studies

EXPLORE →

FacialSkin®

Live ex vivo human skin models containing mature pilosebaceous units and tissue features relevant to facial biology. Suitable for:

  • Sebaceous gland biology
  • Sebum production
  • Personal care innovation

EXPLORE →

Frequently asked questions

Can Genoskin support cosmetic claim substantiation?

Genoskin studies can generate human-relevant biological evidence to support cosmetic R&D, ingredient selection, formulation optimization, and claim-support strategies. Depending on the intended claim, ex vivo data may complement instrumental, clinical, consumer, or other supporting studies.

Can you test both ingredients and finished formulations?

Yes. Genoskin can support studies with active ingredients, raw materials, prototypes, benchmark products, and finished formulations. Study design can be adapted to the product format, intended route of application, exposure time, and biological question.

What cosmetic claims can be explored?

Genoskin models can support exploratory and mechanistic studies related to skin tolerance, soothing effect, barrier support, hydration, repair, anti-aging, photoprotection, oxidative stress reduction, scalp health, and formulation performance.

What endpoints can be measured?

Endpoints can include histology, tissue viability, cytokines and chemokines release analysis, gene expression, spatial biology, protein markers, image analysis, immune-cell response, barrier-related readouts, and donor-to-donor variability.

Why use ex vivo human skin instead of reconstructed skin models?

Reconstructed skin models are useful for standardized screening, but they do not fully reproduce the complexity of native human skin. Genoskin models preserve real tissue architecture, resident cells, appendages, immune functionality, and donor variability, helping cosmetic teams generate more human-relevant biological insight earlier in development.

Can donor characteristics be selected?

Depending on tissue availability and study objectives, donor criteria such as age, gender, phototype, anatomical origin, or specific tissue features may be considered during study planning.