Scientific posters

The identification of safer next-generation drug candidates that do not trigger injection site reactions represents a major challenge. Genoskin uses stabilized immunocompetent skin explants from multiple donors of different age and sex to assess the extent to which therapeutic molecules may trigger these reactions.

HypoSkin^® is the only human skin model to study subcutaneous injections. It contains all three layers of human skin, i.e. epidermis, dermis and hypodermis with normal fat tissue architecture. This model enables the evaluation of local inflammatory reactions following subcutaneous injection of formulations.

We demonstrated that NativeSkin^® can be cultured for up to 10 days while preserving normal skin integrity, significant cell viability, proliferative cells and low levels of apoptosis. Our next step will be to evaluate the activity of specific human skin cytochromes involved in the metabolization of drugs topically applied on NativeSkin^®.

Genoskin’s InflammaSkin^® psoriasis skin model us a T cell-driven skin inflammation model for psoriasis. This cutting-edge assay contains adipose tissue and is designed to assess the efficacy of subcutaneously-delivered anti-inflammatory treatments.

InflammaSkin^® is a T-cell driven ex vivo human psoriasis skin model to test anti-inflammatory drugs. This skin model can be used to assess pharmacological responses following topical prophylactic and therapeutic treatments.

NativeSkin^® is a patented human skin model that allows the culture, treatment, and manipulation of human skin for research and analysis. This model can be used to predict human skin response to treatments. The presence of live human immune cells enables the study of allergen uptake during epicutaneous immunotherapy.

HypoSkin^® is a fully functional ex vivo human skin model that is relevant for studies on the human skin microbiome and to assess changes in skin microbiota following treatment with dermo-cosmetic products.

The wounded HypoSkin^® model is suitable to study wound infection. This model gives you the opportunity to evaluate topical therapies and dressings after prophylactic administration, to prevent wound infection, or assess therapeutic treatment for infected wounds.

Light-sheet fluorescence microscopy (LSFM) is an attractive approach that has shown promise for the acquisition of volumetric data of thick tissues. When combined with optical clearing methods, LSFM allows in-depth optical sectioning and generation of 3D images of entire human skin biopsies.