Presented Scientific Research & Data
Discover our scientific posters
Below you’ll find a list of scientific posters that show how Genoskin helps science move forward using cutting-edge technology. Our Research & Development Department creates increasingly innovative skin models with a high predictive value for reliable study results. We constantly broaden our range of applications to help industries test drugs and compounds on models that are adapted to their needs. Our research mainly focuses on skin metabolism and pathological skin models.
Assessing subcutaneous injection site reactions
The identification of safer next-generation drug candidates that do not trigger injection site reactions represents a major challenge. Genoskin uses stabilized immunocompetent skin explants from multiple donors of different age and sex to assess the extent to which therapeutic molecules may trigger these reactions.
HypoSkin®, skin model for subcutaneous injections
HypoSkin® is the only human skin model to study subcutaneous injections. It contains all three layers of human skin, i.e. epidermis, dermis and hypodermis with normal fat tissue architecture. This model enables the evaluation of local inflammatory reactions following subcutaneous injection of formulations.
NativeSkin®, maintaining skin integrity and metabolism
We demonstrated that NativeSkin® can be cultured for up to 10 days while preserving normal skin integrity, significant cell viability, proliferative cells and low levels of apoptosis. Our next step will be to evaluate the activity of specific human skin cytochromes involved in the metabolization of drugs topically applied on NativeSkin®.
InflammaSkin®, study of the efficacy of anti-inflammatory treatment
Genoskin’s InflammaSkin® psoriasis skin model us a T cell-driven skin inflammation model for psoriasis. This cutting-edge assay contains adipose tissue and is designed to assess the efficacy of subcutaneously-delivered anti-inflammatory treatments.
NativeSkin®, an immunocompetent skin model to study antigen uptake
NativeSkin® is a patented human skin model that allows the culture, treatment, and manipulation of human skin for research and analysis. This model can be used to predict human skin response to treatments. The presence of live human immune cells enables the study of allergen uptake during epicutaneous immunotherapy.
Woundskin®, an innovative model to study wound healing
The wounded HypoSkin® model is suitable to study wound infection. This model gives you the opportunity to evaluate topical therapies and dressings after prophylactic administration, to prevent wound infection, or assess therapeutic treatment for infected wounds.
Light-sheet microscopy technology, in-depth skin structure visualization
Light-sheet fluorescence microscopy (LSFM) is an attractive approach that has shown promise for the acquisition of volumetric data of thick tissues. When combined with optical clearing methods, LSFM allows in-depth optical sectioning and generation of 3D images of entire human skin biopsies.