Vaccine Development

Understanding early immune responses to vaccination is essential for developing safe and effective vaccines. However, conventional preclinical models often struggle to reproduce the complexity of human skin immunity, particularly the interactions between resident immune cells at the injection site.
In this application note, we explore how VaxSkin^®, Genoskin’s human ex vivo skin-based immunoprofiling platform, enables the investigation of vaccine-induced immune responses at both tissue and single-cell levels. Using the mRNA-1273 COVID-19 vaccine as a case study, VaxSkin^® combines cytokine profiling, transcriptomics, and spatial biology to characterize the early immune events triggered by vaccination.

Through experimental findings, the application note illustrates how VaxSkin^® can be used to:

• Characterize cytokine and chemokine release following vaccine injection
• Investigate molecular pathways involved in early immune responses
• Identify skin-resident immune cell populations involved in vaccine responses
• Assess antigen-presenting cell activation and spatial interactions within human skin

Download the application note to explore how VaxSkin^® supports human-relevant vaccine immunogenicity assessment and provides insights to inform vaccine development.

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