Case Study

Injection site reactions (ISRs) are a common challenge in injectable drug development, potentially affecting patient comfort and treatment adherence. Cetrorelix, a GnRH antagonist used in assisted reproduction, is known to cause local reactions following subcutaneous injection.

In this case study, Genoskin investigated Cetrorelix-induced ISRs using its HypoSkin^® ex vivo human skin model, combining cytokine profiling and computational pathway analysis across 7 independent donors. The study identified inflammatory signatures and biological pathways associated with type 2 immune responses, neuroinflammation, and vascular regulation, consistent with previously reported clinical observations.

Download the case study to explore the experimental approach, cytokine responses, and biological pathways identified following Cetrorelix injection.

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