Detecting early immunogenicity with HypoSkin^®

Evaluating unwanted immune responses to biologics and vaccines remains a challenge in preclinical drug development. Conventional models may not fully reproduce the complex cellular interactions and immune environment of human skin.
HypoSkin^® is an immunocompetent ex vivo human skin model that preserves the epidermis, dermis, and hypodermis, including resident immune cells. Designed for intradermal and subcutaneous injections, it provides a human-relevant platform for investigating local tissue responses and early immunogenicity-related events.

This white paper presents experimental validation of HypoSkin^®, including structural integrity, injection compatibility, and cellular stability over time. Using histology, advanced imaging, and single-cell RNA sequencing, it examines the preservation of skin architecture, immune cell populations, and gene expression profiles during culture.

Download the white paper to explore the validation data and discover how HypoSkin^® can support early immunogenicity assessment and injectable drug development.