Understanding psoriasis-like inflammation in a human-relevant context with InflammaSkin®
Psoriasis is a complex inflammatory skin disease involving immune dysregulation, keratinocyte responses, and T cell-driven pathways. Understanding these mechanisms and evaluating new therapeutic approaches requires human-relevant models that capture the complexity of immune-mediated inflammation.
Genoskin’s InflammaSkin® model reproduces key features of psoriasis-like inflammation, including T cell activation, immune cell changes, and a Th1/Th17-like inflammatory profile.
Recent data demonstrate increased secretion of disease-relevant inflammatory mediators, including IL-17A, IFN-γ, IL-22, TNF-α, and GM-CSF. The model also responds to targeted immunomodulation, with Betamethasone and Cosentyx® reducing inflammatory cytokine release.
InflammaSkin® provides a human ex vivo platform to investigate inflammatory mechanisms and evaluate therapeutic strategies for psoriasis and other immune-mediated skin diseases.
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