Local Toxicity and Formulation Safety: An argenx Collaboration Study
Formulation safety testing still relies heavily on in vivo studies due to limited validated in vitro alternatives. Genoskin’s HypoSkin® biostabilized ex vivo human skin enables multi-parametric local tolerance assessment after subcutaneous injection. In a validation study, the model detected toxic control formulations with strong in vitro–in vivo correlation, using robust macroscopic imaging and histopathology endpoints for standardized scoring.
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