Top-level science through the eyes of an expert.
Join us for the 9th webinar in Genoskin’s scientific series, where we continue to explore groundbreaking advancements in immunology and human skin biology. This session will feature an in-depth presentation by Dr. Etienne Meunier, a leading expert in inflammasome biology and innate immunity, group leader at IPBS, Toulouse, France. This episode of the Naked Immunology Webinar Series is now scheduled on February 26, 2025 at 8 a.m. (PST), 11 a.m. (EST), 5 p.m. (CET). The webinar is open to English-speaking participants with a solid scientific background.
This session will feature an in-depth presentation of the NLPR Inflammasome by Dr. Etienne Meunier, a leading expert in innate immunity, immune detection and elimination of pathogens.
Discover the cutting-edge research on the NLRP1 inflammasome in this engaging webinar featuring Dr. Etienne Meunier.
Inflammasomes are critical intracellular protein complexes that play a pivotal role in immunity against pathogens. They regulate pyroptosis—a form of programmed cell death—and release key inflammatory cytokines such as IL-1β and IL-18, essential for controlling microbial infections. While much of our understanding of inflammasomes stems from rodent models or immune cell studies, these do not fully capture the unique characteristics of human inflammasomes.
This webinar will explore the novel immune functions of the human NLRP1 inflammasome, predominantly expressed in epithelial tissues like skin and airways, in response to environmental and infectious threats. Join us as we delve into the ribotoxic stress response pathway and its implications for understanding immune defense in human biology.
Resources related to Dr. Meunier’s inflammasome research
• Planès R, Pinilla M, Santoni K, et al.Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82(13):2385-2400.e9.
• Pinilla M, Mazars R, Vergé R, et al.EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med.
• Rozario P, Pinilla M, Gorse L, et al.Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2024;121(2):e2309579121.
Register now to gain valuable insights into human immune defense mechanisms!
About the speaker:
Dr. Etienne Meunier
Group leader at IPBS, Toulouse, France.Dr. Etienne Meunier brings a wealth of expertise in innate immunity and inflammasome biology. With a PhD from Toulouse, France, and a postdoctoral tenure in Basel, Switzerland, he has made groundbreaking discoveries on host cytosolic anti-bacterial immunity and inflammasome activation mechanisms. Now leading his own laboratory at the IPBS institute, Dr. Meunier’s work focuses on understanding human-specific regulators of immune responses.
Recognized with prestigious awards such as the CNRS Bronze Medal, Dr. Meunier is at the forefront of exploring how human epithelial inflammasomes contribute to health and disease.
Additional resources on Dr. Meunier’s previous work
• Lefèvre L, Lugo-Villarino G, Meunier E, et al.The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity. 2013;38(5):1038-1049.
• Meunier E, Dick MS, Dreier RF, et al.Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014;509(7500):366-370.
• Meunier E, Wallet P, Dreier RF, et al.Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol. 2015.
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