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Top things found in human skin (vs in reconstructed human skin models) Covering nearly two square meters, skin is our body’s largest organ and a common pathway for administering drugs—whether through topical applications, subcutaneous injections, intradermal routes, or medical devices. With its complex network of immune cells, the skin plays an essential role in testing the efficacy and safety ofRead more

Research HighlightExplore our latest publication in Allergy: the story behind the idea and key findings.The landscape of vaccine research is undergoing an important transformation, thanks to the breakthroughs in mRNA vaccine technology. This innovation has catalyzed the development of vaccines that are not only highly effective but also rapidly deployable at a large scale. With the increasing number of researchRead more

Unlocking the Future of Immunization - The Rise of Systems Vaccinology in Modern Vaccine DevelopmentIn the ever-evolving landscape of immunology, the emergence of systems biology has catalyzed a transformative approach to vaccine development, known as systems vaccinology. This interdisciplinary field transcends traditional methodologies by integrating vast amounts of biological data to provide a holistic understanding of how vaccines interact withRead more

Accelerating Vaccine Development with TranscriptomicsThe landscape of vaccine development is undergoing a significant transformation with the advent of transcriptomic approaches. These technologies offer unprecedented insights into the complexities of the immune system, enabling the creation of more effective and targeted vaccines. Understanding Transcriptomics In the cutting-edge field of vaccine development, transcriptomics stands out as a revolutionary approach, offering unprecedented insightsRead more

Injection-Site PainWhich factors influence pain upon subcutaneous injection?Biologics such as vaccines, insulin, monoclonal antibodies, etc., that are now widely developed need to be administered parenterally. While the intravenous (IV) route has historically been the most widely used,  the subcutaneous (SC) route is now accepted and presented as safe and effective, whether in the context of chronic disease or in palliativeRead more

Immunogenicity SeriesPart 4 - Evaluating and managing immunogenicity for vaccinesImmunogenicity is crucial in vaccine development, it represents the capacity of a substance, such as a vaccine, to elicit an immune response. This reaction can be beneficial, providing protection against diseases, or detrimental, resulting in adverse effects. In vaccine development, the goal is to trigger on-target immunogenicity to activate the immuneRead more