Blog

Injection-Site PainWhich factors influence pain upon subcutaneous injection?Biologics such as vaccines, insulin, monoclonal antibodies, etc., that are now widely developed need to be administered parenterally. While the intravenous (IV) route has historically been the most widely used,  the subcutaneous (SC) route is now accepted and presented as safe and effective, whether in the context of chronic disease or in palliativeRead more

Immunogenicity SeriesPart 4 - Evaluating and managing immunogenicity for vaccinesImmunogenicity is crucial in vaccine development, it represents the capacity of a substance, such as a vaccine, to elicit an immune response. This reaction can be beneficial, providing protection against diseases, or detrimental, resulting in adverse effects. In vaccine development, the goal is to trigger on-target immunogenicity to activate the immuneRead more

HypoSkin®, an ex vivo human skin model to predict toxicity & efficacy of subcutaneous drugs Recent advancements in subcutaneous injection testing have brought about significant improvements in drug delivery and patient experience. These advancements include the development of innovative injection devices and formulations that enhance the ease and comfort of subcutaneous drug administration. Market trends also indicate a growing demandRead more

Understanding Pain & Neurogenic InflammationCan our understanding of pain and neurogenic inflammation help in predicting and managing injection-related pain?Nociception, the neural processes of encoding and processing noxious stimuli, and the sensation of pain are initiated by extreme pressures, temperatures, toxic substances, and inflammatory mediators capable of causing tissue injury. These strong stimuli are recognized by specific nerve cells in theRead more

Ask the Expert: Your Top Questions About Genoskin’s Mast Cell Platform Answered Curious about mast cells and their role in injection site reactions? Learn about how Genoskin sources and cultures human primary mast cells, the unique qualities of our mast cell research solution, and its diverse applications in drug toxicity assessment, allergic reaction evaluation, and vaccine development. 1. How doRead more

Assessment of injection site reactionsA new proprietary research tool to identify drug-related immune adverse reactions in human skinToday, biologics represent one of the fastest growing markets within the pharmaceutical industry.The pipeline of biological drugs is growing at a rapid pace with a global market expected to reach over 460 billion USD in 2024 (1). In order to bypass gastric metabolism,Read more