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Understanding Pain & Neurogenic InflammationCan our understanding of pain and neurogenic inflammation help in predicting and managing injection-related pain?Nociception, the neural processes of encoding and processing noxious stimuli, and the sensation of pain are initiated by extreme pressures, temperatures, toxic substances, and inflammatory mediators capable of causing tissue injury. These strong stimuli are recognized by specific nerve cells in theRead more

Ask the Expert: Your Top Questions About Genoskin’s Mast Cell Platform Answered Curious about mast cells and their role in injection site reactions? Learn about how Genoskin sources and cultures human primary mast cells, the unique qualities of our mast cell research solution, and its diverse applications in drug toxicity assessment, allergic reaction evaluation, and vaccine development. 1. How doRead more

Assessment of injection site reactionsA new proprietary research tool to identify drug-related immune adverse reactions in human skinToday, biologics represent one of the fastest growing markets within the pharmaceutical industry.The pipeline of biological drugs is growing at a rapid pace with a global market expected to reach over 460 billion USD in 2024 (1). In order to bypass gastric metabolism,Read more

Navigating Unwanted ImmunogenicityPart 3 - Challenges & insights in biologic drug developmentOver the past two and a half decades, biologics development has been growing exponentially, matching the pace of small molecules development in 20221. Biologics, or biopharmaceutical products, encompass a wide range of therapeutic products such as vaccines, monoclonal antibodies, gene and cell therapy, and recombinant and fusion therapeutic proteins.Read more

Genoskin at the European Mast Cell and Basophil Research Network meeting in ToulouseAdvancing mast cell research through in vitro evaluation of mast cell responsesWe were thrilled to participate in the prestigious European Mast cell and Basophil Research Network (EMBRN) Conference, which took place in Genoskin’s hometown, Toulouse, France, from May 29-31, 2024. This event brought together prominent academic researchers, clinicians,Read more

Transforming Drug SafetyThe Revolutionary Role of Investigative Toxicology in Drug DevelopmentIn an era where the pace of pharmaceutical innovation is rapidly evolving, the field of toxicology is undergoing a transformative shift. This goes beyond subtle changes; there is a fundamental reimagining of its role from observing drug-induced effects to proactively shaping drug safety measures.The Integration of Investigative Toxicology The traditionalRead more