Drug Development

2
May

Unwanted Immunogenicity

Navigating Unwanted ImmunogenicityPart 3 - Challenges & insights in biologic drug developmentOver the past two and a half decades, biologics development has been growing exponentially, matching the pace of small molecules development in 20221. Biologics, or biopharmaceutical products, encompass a wide range of therapeutic products such as vaccines, monoclonal antibodies, gene and cell therapy, and recombinant and fusion therapeutic proteins.
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16
Apr

Investigative toxicology

Transforming Drug SafetyThe Revolutionary Role of Investigative Toxicology in Drug DevelopmentIn an era where the pace of pharmaceutical innovation is rapidly evolving, the field of toxicology is undergoing a transformative shift. This goes beyond subtle changes; there is a fundamental reimagining of its role from observing drug-induced effects to proactively shaping drug safety measures.The Integration of Investigative Toxicology The traditional
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29
Feb

The Silent Crisis in Biomedical Research: Beyond Macaques

The Silent Crisis in Biomedical Research: Beyond MacaquesFinding an alternative to non-human primates to evaluate human therapeutics In a compelling narrative echoed by Le Monde, the biomedical sector faces a silent crisis, highlighting the geopolitical intricacies and ethical quandaries of scientific research. At its core, the dwindling supply of non-human primates (NHPs), particularly macaques, essential for testing medical treatments, has
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29
Feb

Immunogenicity series: Wanted Immunogenicity for Vaccine Development

Immunogenicity SeriesPart 2 - Wanted Immunogenicity for Vaccine DevelopmentImmunogenicity is a key concept in vaccine development,referring to the ability of a vaccine to stimulate an immune response in the recipient. It is a desirable and critical characteristic because the effectiveness of a vaccine is directly linked to its ability to induce a robust and protective immune response. Vaccine Development: Global
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9
Feb

Understanding Local Tolerance

Understanding Local Tolerancein Drug DevelopmentIn the ever-evolving field of drug development, ensuring the safety and efficacy of new therapeutic agents is paramount. A crucial aspect of this safety evaluation is the assessment of cytotoxicity – the potential of substances to harm or destroy cells. Particularly in the realm of skin cytotoxicity, the concept of Local Tolerance, especially in the context
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10
Jan

Immunogenicity series: Defining immunogenicity

Immunogenicity SeriesPart 1 - Defining immunogenicity Immunogenicity plays a pivotal role in drug and vaccine development and is essential for optimizing therapeutic efficacy and safetyby understanding the immune system's response to the compounds being tested. This is particularly crucial in the era of biologics and personalized medicine, where the fine balance between therapeutic benefit and immune reactivity is critical. Whether
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