Skin Science

Integrating microbiome science with cosmetic product developmentBeyond clean claims, the emergence of skin microbiome in skin careSkin care is entering a new era, one where skin biology, consumer insight, and smart formulation converge to shape innovation. At the center of this shift, the skin microbiome has emerged as a key focus, opening new pathways for cosmetic testing and research, drivingRead more

Top things found in human skin (vs in reconstructed human skin models) Covering nearly two square meters, skin is our body’s largest organ and a common pathway for administering drugs—whether through topical applications, subcutaneous injections, intradermal routes, or medical devices. With its complex network of immune cells, the skin plays an essential role in testing the efficacy and safety ofRead more

HypoSkin®, an ex vivo human skin model to predict toxicity & efficacy of subcutaneous drugs Recent advancements in subcutaneous injection testing have brought about significant improvements in drug delivery and patient experience. These advancements include the development of innovative injection devices and formulations that enhance the ease and comfort of subcutaneous drug administration. Market trends also indicate a growing demandRead more

Understanding Pain & Neurogenic InflammationCan our understanding of pain and neurogenic inflammation help in predicting and managing injection-related pain?Nociception, the neural processes of encoding and processing noxious stimuli, and the sensation of pain are initiated by extreme pressures, temperatures, toxic substances, and inflammatory mediators capable of causing tissue injury. These strong stimuli are recognized by specific nerve cells in theRead more

Understanding Local Tolerance in drug developmentIn the ever-evolving field of drug development, ensuring the safety and efficacy of new therapeutic agents is paramount. A crucial aspect of this safety evaluation is the assessment of cytotoxicity – the potential of substances to harm or destroy cells. Particularly in the realm of skin cytotoxicity, the concept of Local Tolerance, especially in theRead more

Advancing New Approach Methodologies for ethical & reliable drug development New Approach Methodologies: Changing drug development as we know it Drug development is long, expensive, and painfully inefficient. With 90% of drug candidates failing before clinical approval, the industry is desperate for human-relevant, predictive tools—this is where New Approach Methodologies (NAMs) have emerged as a vital solution. At Genoskin, weRead more