Toxicology

At the 2026 annual meeting of the Society Of Toxicology (SOT), we will present new data demonstrating the value of our HypoSkin® ex vivo human skin platform as a translational human-based New Approach Methodology (NAM) for early safety assessment. The poster, developed in collaboration with argenx, will highlight how our platform can support early local tolerance screening and help reduce reliance on animal testing in formulation safety evaluation.

Conferences & eventsCome & meet our amazing teamGenoskin at the SOT 65th Annual Meeting & ToxExpoDriving innovation in non-clinical toxicity assessment with ex vivo human skin and mast cell models Genoskin was pleased to return to the SOT Annual Meeting and ToxExpo, taking place March 22–25, 2026, at the San Diego Convention Center in San Diego, California. Recognized as oneRead more

Download this application note and discover 3 case studies. Refine formulations or assess local tolerance in human skin before clinical trials.

Prove ADCC Activityin real human skinFor therapies targeting mast cells, demonstrating antibody-dependent cell-mediated cytotoxicity (ADCC) in complex human tissue is essential.Traditional in vitro assays provide limited context, leaving critical aspects of biological impact unclear. HypoSkin® offers a solution Our ex vivo human skin model lets you assess mast cell depletion in situ, offering a powerful, human-relevant platform to confirm theRead more

Advancing medical device development with ex vivo human skinMedical devices are evolving rapidly, becoming more sophisticated and diverse in their applications. From injectable drug delivery systems to wound dressings, wearable sensors, and microneedles, these innovations must undergo rigorous testing to ensure safety, functionality, and biocompatibility. However, as medical devices become more complex, so do the challenges associated with their preclinicalRead more

Beyond animal models: The role of human skin in ADME testingADME (Absorption, Distribution, Metabolism, and Excretion) testing plays a vital role in modern drug development by improving candidate selection, reducing failures, enhancing safety assessments, ensuring regulatory compliance, and ultimately saving time and resources in bringing new drugs to market. Traditionally, ADME testing has relied on animal models and in vitroRead more