NativeSkin^® & Cosmetics

From hydration and barrier repair to irritation risk and anti-aging performance, today’s cosmetic R&D demands data that is predictive, reproducible, and aligned with non-animal testing strategies. But many conventional models fail to capture what makes skin truly “human”: an intact barrier, native cellular complexity, and real tissue architecture.

In this application note, discover how NativeSkin^®, Genoskin’s live ex vivo human skin model, supports robust efficacy and safety testing of cosmetic ingredients and formulations under controlled, standardized conditions. NativeSkin^® preserves key features of real human skin, including epidermis and dermis structure, barrier function, and functional immune components, enabling deeper insight into product performance and tolerance.

Inside, you’ll explore how NativeSkin^® can be used for:

• Efficacy testing (hydration, barrier function, anti-aging/ECM protection, metabolism)
• Safety evaluation (irritation and inflammation endpoints, sensitive skin relevance)
• Skin biology readouts relevant to cosmetics, including pigmentation and microbiome-oriented research
• Translational case examples spanning photoprotection, irritation mechanisms, and anti-aging validation

Download the application note to explore how NativeSkin^® supports human-relevant cosmetic efficacy and safety testing, helping you strengthen claims, de-risk formulations earlier, and generate data that better reflects real-world skin responses.