Skin Microbiome

The human skin is colonized by a diverse population of microorganisms. The symbiotic host-microorganism relationship can be affected by numerous endogenous and exogenous factors. This can result in skin disorders or infection. In vitro human skin model equivalents have been developed to assess the interaction between the skin and the microbiota. However, most studies have only looked at the impact of individual microbiota species. Genoskin has developed HypoSkin^®, a fully functional ex vivo human skin model with the three skin layers based on NativeSkin^® explant technology. The objectives of this study were to characterize the skin microbiota in the different layers of the HypoSkin^® ex vivo human skin model over seven days. We studied microbiota evolution throughout the culture using state-of-the-art Vaiomer’s proprietary technology based on 16S ribosomal RNA.

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