Drug Development

Understanding Local Tolerancein Drug DevelopmentIn the ever-evolving field of drug development, ensuring the safety and efficacy of new therapeutic agents is paramount. A crucial aspect of this safety evaluation is the assessment of cytotoxicity – the potential of substances to harm or destroy cells. Particularly in the realm of skin cytotoxicity, the concept of Local Tolerance, especially in the contextRead more

Immunogenicity SeriesPart 1 - Defining immunogenicity Immunogenicity plays a pivotal role in drug and vaccine development and is essential for optimizing therapeutic efficacy and safetyby understanding the immune system's response to the compounds being tested. This is particularly crucial in the era of biologics and personalized medicine, where the fine balance between therapeutic benefit and immune reactivity is critical. WhetherRead more

Redefining Local Toxicity AssessmentPart 2 - The Role of Animal-Free Non-Clinical Platforms in Drug Development. In the realm of non-clinical animal-free platforms, a transformative shift is unfolding in response to the challenges posed by drug-induced adverse reactionsa predominant factor leading to the discontinuation of drug development projects and the withdrawal of drugs from the market1. The imperative for accurate, ethical,Read more

Redefining Local Toxicity AssessmentPart 1 - The Role of Animal-Free Non-Clinical Platforms in Drug DevelopmentIn the intricate world of drug development, the quest for precision, safety, and efficacy is unending.Traditional toxicity assessment methods using animal models, while historically significant, have shown discernible limitations in their predictability of human responses. As the biotech and pharma sectors continue to push the boundariesRead more

Top-level science through the eyes of an expert.The sixth Webinar. This webinar episode is open to English-speaking participants with a solid scientific background. Featured speaker is Dr. Laurent Reber, Laboratory Director at the Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy, France) and Principal Investigator at the French National Institute of Health and Medical Research (INSERM, France). watch the replayRead more

Why testing & mitigating Injection Site Reactions is critical during drugs/vaccines development? Injection site reactions (ISR) are a common occurrence when a person receives an injection in the skin, such as a vaccine or self-administered biologics.These reactions occur due to the activation of the immune system at the injection site. When a foreign substance, such as a vaccine or medication,Read more