This session will feature an in-depth presentation of the NLPR Inflammasome by Dr. Etienne Meunier, a leading expert in innate immunity, immune detection and elimination of pathogens.
Discover the cutting-edge research on the NLRP1 inflammasome in this engaging webinar featuring Dr. Etienne Meunier.
Inflammasomes are critical intracellular protein complexes that play a pivotal role in immunity against pathogens. They regulate pyroptosis—a form of programmed cell death—and release key inflammatory cytokines such as IL-1β and IL-18, essential for controlling microbial infections. While much of our understanding of inflammasomes stems from rodent models or immune cell studies, these do not fully capture the unique characteristics of human inflammasomes.
This webinar will explore the novel immune functions of the human NLRP1 inflammasome, predominantly expressed in epithelial tissues like skin and airways, in response to environmental and infectious threats. Join us as we delve into the ribotoxic stress response pathway and its implications for understanding immune defense in human biology.
Resources related to Dr. Meunier’s inflammasome research
• Planès R, Pinilla M, Santoni K, et al.Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82(13):2385-2400.e9.
• Pinilla M, Mazars R, Vergé R, et al.EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med.
• Rozario P, Pinilla M, Gorse L, et al.Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2024;121(2):e2309579121.
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