Immunology

Home / Resources / Blog Blog Mast cell depletion mechanisms: From biological rationale to human-relevant testingWhy mast cells are important Mast cells are tissue-resident immune cells best known for their role in allergic reactions, but their function extends far beyond allergy. Located in barrier tissues such as the skin, airways, and gastrointestinal tract, they help detect environmental triggers, pathogens, tissueRead more

Top-level science through the eyes of an expert.Preclinical evaluation of an energy-driven device for localized skin delivery of nucleic acidsDid you miss the live session? The full webinar recording is now available to watch on demand. Explore preclinical insights into an energy-driven, microneedle-based device enabling localized, non-viral delivery of naked nucleic acids to skin, highlighting transgene expression, immune activation, andRead more

Prove ADCC Activityin real human skinFor therapies targeting mast cells, demonstrating antibody-dependent cell-mediated cytotoxicity (ADCC) in complex human tissue is essential.Traditional in vitro assays provide limited context, leaving critical aspects of biological impact unclear. HypoSkin® offers a solution Our ex vivo human skin model lets you assess mast cell depletion in situ, offering a powerful, human-relevant platform to confirm theRead more

Explore how HypoSkin®—a standardized, injectable, and immunocompetent human skin model—provides a translational, animal-free solution for assessing the immunogenicity of therapeutic compounds. From structural stability to real-time immune response profiling, this white paper delivers data-backed insights designed for pharma and biotech teams advancing injectable drug development.

Top-level science through the eyes of an expert.Join us for the next session of Naked Immunology Webinar series, where we explore cutting-edge advancements in drug delivery and therapeutic innovation. In this session we will discuss how the immune system’s reaction to neuromuscular blockers could offer new therapeutic insights. WATCH NOWThis webinar explores new insights into the antibody responses of patientsRead more

From human skin to human data: Advancing immunogenicity testing with human modelsIn a public workshop organized by the FDA-CRCG group, Dr. Nicolas Gaudenzio, CSO of Genoskin, introduced an innovative platform for assessing immune reactions in response to injected substances using human skin explants. His talk, titled "A new in vitro framework for assessing immunogenicity using comprehensive profiling of injectable humanRead more