Posters

Prove ADCC Activity in Real Human Skin For therapies targeting mast cells, demonstrating antibody-dependent cell-mediated cytotoxicity (ADCC) in complex human tissue is essential. Traditional in vitro assays provide limited context, leaving critical aspects of biological impact unclear. HypoSkin® offers a solution Our ex vivo human skin model lets you assess mast cell depletion in situ, offering a powerful, human-relevant platformRead more

Mast CellsSingle-cell profiling of biostabilized natural human skin identifies mast cells as an important target of injected mRNA-1273 COVID-19 vaccine. Research by M. Scholaert1,2, M. Peries2, E. Braun2, J. Martin1, N. Serhan1, A. Loste1, A. Bruner1, L. Basso1, E. Merle2, A. Trevisiol2, E. Pagès2 and N. Gaudenzio1,2 1Toulouse Insitute for Infectious and Inflammatory Diseases (Infinity), 2Genoskin The field of vaccinationRead more

Skin MicrobiomeA fully functional ex vivo human skin model to study human skin microbiome Research by B. Coupe1, M. Pastore2, E. Pagès2, E. Braun2, A. Broha1, P. Descargues2 1Vaiomer, 2Genoskin The human skin is colonized by a diverse population of microorganisms. The symbiotic host-microorganism relationship can be affected by numerous endogenous and exogenous factors. This can result in skin disordersRead more

Genoskin presents WoundSkin^®, an infected wounded ex vivo skin model suited to assess the efficacy of wound-healing formulations.

Skin ModelsPreservation of human skin integrity and metabolism during 10 days in culture with NativeSkin® system Research by E. Raude1, E. Pagès1, M. Pastore1, P.-O. Cuoc2, L. Malaquin3, P. Descargues1 1Genoskin, 2Promega, 3LAAS-CNRS Scientific Context Human epidermis is not vascularized and oxygen only reaches epidermal cells by diffusing through the stratum corneum or from the dermal papillae which contains aRead more

Skin ModelsNativeSkin®, an immunocompetent human skin model to study antigen uptake and processing by Langerhans cells Research by E. Pagès1, L. Mondoulet3, E. Bonnefont1, E. Braun1, V. Dhelft2, C. Dupont3, H. Sampson2, P. Descargues1 1Genoskin, 2DBV Technologies, 3Hôpital Necker, Université Paris-Descartes Scientific Context Epicutaneous immunotherapy (EPIT) using Viaskin® patches has been shown to induce tolerance in sensitized mice (Dioszeghy, ClinRead more